SARS-CoV-2 Nsp14 binds Tollip and activates pro-inflammatory pathways while downregulating interferon-α and interferon-γ receptors.

Therefore, we performed RT-qPCR to examine levels of the N gene-containing RNAs at 24 hours post-infection and observed only a modest decrease in the presence of Tollip knockdown as compared with the control, and the difference did not reach statistical significance ( Fig. 7D ).

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