NR2F6 as a Disease Driver and Candidate Therapeutic Target in Experimental Cerebral Malaria.

Yielding a p -value < 0.05, the difference was considered significant (*), while highly significant results with a p -value < 0.01 or even <0.001 were marked with “**” or “***”, respectively.

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As there was only a slight trend in parasitemia with high variation, we speculate that there is no enhanced systemic resistance to the malaria parasite overall.

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( Figure 1 B) Regarding the parasitemia, infected Nr2f6 -knock-out mice showed a trend to an attenuated phenotype until day 7, but increased dramatically until day 11 p.i., where mice had to be euthanized due to the development of hyperparasitemia (up to 30% parasitemia) ( Figure 1 C).

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