Microvascular, Biochemical, and Clinical Impact of Hyperbaric Oxygen Therapy in Recalcitrant Diabetic Foot Ulcers.

Cells · 2025 · PMC12346236 · PMID 40801628

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a decreasing trendno p-value reported

After three months of HBOT, both VEGF and PlGF levels showed a decreasing trend, which may reflect a reduction in tissue hypoxia and a concurrent decline in inflammatory mediators.

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showed a trendno p-value reported

Histological analysis showed a trend for increased CD31+ microvessel density in the HBOT DFU after 1 month of treatment (617 vs. 709 microvessels, as counted across three fields under 200× magnification).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.