The Pharmacokinetic and Pharmacodynamic Relationship of Clinically Used Antiseizure Medications in the Maximal Electroshock Seizure Model in Rodents.

We observed a dose–response curve at doses ranging from 5 to 35 mg/kg; however, despite finding a 50% reduction in seizure score compared to the vehicle-treated group, the results did not reach statistical significance ( p = 0.12, ED 50 = 42.9 mg/kg).

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