Efficacy of Adding Immune Checkpoint Inhibitors to Chemotherapy Plus Bevacizumab in Metastatic Colorectal Cancer: A Meta-Analysis of Randomized Controlled Trials.

Secondary Outcomes The meta-analysis for OS, which was assessed in four [ 9 , 10 , 11 , 12 , 13 ] studies, demonstrated a trend of better OS in the With-ICI group than in the Without-ICI group, but the difference did not reach statistical significance, with an HR of 0.91 (95% CI: 0.74–1.12, p = 0.39) ( Figure 3 ), and no significant between-study heterogeneity was observed (χ 2 = 1.13, I 2 = 0%, p = 0.77).

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No significant improvements were observed between the With- and Without-ICI groups in OS and ORR meta-analyses, but the With-ICI group had a favorable trend in OS.

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