Decoding Treatment Failures in Metastatic Renal Cell Carcinoma: Predictors Across Immunotherapy and Targeted Therapies from a Retrospective Real-World Analysis.

J Clin Med · 2025 · PMC12347088 · PMID 40806892

Europe PMC DOI

hedged sentences

0.0610

closest p · 1.2× alpha

0.2700

boldest claim

The sentences

borderline significancep = 0.061so close (0.05 < p ≤ 0.1)

Two variables showed borderline significance—elevated platelet count ( p = 0.061) and higher neutrophil count ( p = 0.081)—both suggesting a possible inflammatory component associated with reduced treatment durability.

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did not reach statistical significancep = 0.27not close (p > 0.1)

The difference did not reach statistical significance in a Z-test ( p = 0.27).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.