rs2231142 (421 C>A, Q141K) Is More Functionally Influential than rs2231137 (34 G>A, V12M) on Anticancer Drug Resistance Mediated by the <i>ABCG2</i> Haplotype In Vitro.

Int J Mol Sci · 2025 · PMC12347123 · PMID 40806557

Europe PMC DOI

hedged sentence

0.0660

closest p · 1.3× alpha

0.0660

boldest claim

The sentences

showed a trendp = 0.066so close (0.05 < p ≤ 0.1)

While ABCG2 (12M/141Q) conferred the highest resistance among the tested variants, the ABCG2 (12M/141K) haplotype showed a trend toward higher mitoxantrone resistance than the ABCG2 (12V/141Q) (WT) ( p = 0.066), suggesting a haplotype-specific effect.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.

rs2231142 (421 C&gt;A, Q141K) Is More Functionally Influential than rs2231137 (34 G&gt;A, V12M) on Anticancer Drug Resistance Mediated by the &lt;i&gt;ABCG2&lt;/i&gt; Haplotype In Vitro.

The sentences

rs2231142 (421 C>A, Q141K) Is More Functionally Influential than rs2231137 (34 G>A, V12M) on Anticancer Drug Resistance Mediated by the <i>ABCG2</i> Haplotype In Vitro.