TMAO Activates the NLRP3 Inflammasome, Disrupts Gut-Kidney Interaction, and Promotes Intestinal Inflammation.

Int J Mol Sci · 2025 · PMC12347540 · PMID 40806570

Europe PMC DOI

hedged sentences

0.0100

closest p · 0.2× alpha

0.0500

boldest claim

The sentences

highly significantp < 0.01actually significant

Serum TMAO showed a highly significant positive correlation with colonic NLRP3, IL-18, and TNF-α ( p < 0.01) and a significant positive correlation with kidney NLRP3 and IL-1β ( p < 0.05).

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did not reach statistical significancep > 0.05actually significant

Caspase1-p20 levels were significantly elevated in the colonic tissue of the TMAO + model group ( p < 0.05), while the model and TMAO groups exhibited numerical increases that did not reach statistical significance ( p > 0.05).

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