Combining Time-Restricted Wheel Running and Feeding During the Light Phase Increases Running Intensity Under High-Fat Diet Conditions Without Altering the Total Amount of Daily Running.

Several clock genes, including Bmal1 , Clock , and Reverba , showed a trend towards a delayed phase in DRDF-H compared to NR-H, but a significant delay was only confirmed for Bmal1 (3 h 47 m) ( Figure 2 B, Tables S4 and S5 ).

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