3D Tumor microenvironment interaction reveals AP-1 complex regulation and contact-mediated reprogramming of bone marrow stromal cells in chronic lymphocytic leukemia.

Exhausted T cells, defined by PD1, TIM3, and LAG3, showed a trend of activation in CD4 + and CD8 + T cells in the core region (Figure 2F ).

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Moreover, the CD4 + and CD8 + T cell functionality is supported by cytokine secretion and the expression of the co‐inhibitory receptor CTLA‐4 with a slight trend toward higher levels in the core region, especially for IFNγ (Figure 2H ).

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