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Prognostic and Predictive Value of SARIFA-status Within Molecular Subgroups of Colorectal Cancer: Insights From the Netherlands Cohort Study.

Am J Surg Pathol · 2025 · PMC12352556 · PMID 40340947

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Associations between SARIFA-status and CRC-specific and overall survival failed to reach statistical significance within the dMMR subgroup ( P CRC-specific =0.063 and P overall =0.161; Fig. 4 and Supplementary Figure S3, Supplemental Digital Content 1, http://links.lww.com/PAS/C100 ), most likely due to low statistical power of the analysis due to the limited number of patients within this subgroup, and the already known favorable prognosis of patients with dMMR CRC in general 34 (Table 1 ).

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