Targeting immune checkpoint LAIR1 with antibody blockade or 3-in-1 CAR T cells enhances antitumor response.

To investigate the mechanism of action of LAIR1 in M2-like MΦ, we performed scRNA-Seq analysis (the cell population categorization used in the analysis is shown in Supplemental Figure 12 ) using tumor samples from total 6 KR158B-CD70-Luc TB mice treated with IgG or anti-Lair1 antibody, which showed a trend of antitumor efficacy ( Supplemental Figure 13A ).

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