siRNA conjugate with high albumin affinity and degradation resistance for delivery and treatment of arthritis in mice and guinea pigs.

Nat Biomed Eng · 2025 · PMC12354308 · PMID 40379798

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did not reach statistical significanceno p-value reported

Unlike what was seen with siMMP13<(EG 18 L) 2 , modest reductions in OA progression and joint degeneration were achieved in PTOA joints treated with CL-82198, although these trends did not reach statistical significance.

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