Integration of Metabolomics, Transcriptomics, and 16s rRNA Sequencing Reveals the Mechanism of <i>Morus alba</i> <i>L.</i> (Sangzhi) Alkaloids (SZ-A) in Improving Cholesterol Metabolism in Diabetic Rats.

Repeated treatment with 200 mg/kg SZ-A increased fecal TDCA and TLCA content ( p < 0.05, Figure A,B) and elevated the TMCA content by 103.8% ( p > 0.05, Figure C) compared to the Con group. It also decreased the content of 7-KDCA and 12-KLCA ( p < 0.05, Figure D,E) and showed a trend toward lowering TCDCA and CDCA contents ( p > 0.05, Figure F,G).

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