Amitriptyline potently neutralizes distinct SARS-CoV-2 variants including D614G, Omicron BA.5, and Omicron XBB.1.

Front Microbiol · 2025 · PMC12358469 · PMID 40831631

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did not reach statistical significanceno p-value reported

Lower concentrations (5–25 μM) resulted in stepwise reductions in viral load, ranging from ~1 log10 at 10 μM to ~2–3 log10 at 25 μM, although these effects did not reach statistical significance under the given conditions.

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