The activity and expression of adenylosuccinate lyase were reduced during modern human evolution, affecting brain and behavior.

Proc Natl Acad Sci U S A · 2025 · PMC12358879 · PMID 40758872

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nominally significantno p-value reported

In the cerebellum, the corresponding increases were more modest, 1.2- to 1.3-fold, and nominally significant only for the cerebellar cortex of the females ( SI Appendix, Table S3 ).

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