Contrasting Behavioural and Biochemical Characteristics of Normal and Spontaneously α-Synuclein-Deficient Mice Treated With MPTP.

Stereological estimates of nigral TH‐ir cell count (Figure 5B ) showed that MPTP treatment in both genotypes revealed a highly significant reduction in the number of TH‐ir neurons.

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The EPM 3 followed a similar trend to EPM 2, whereby both MPTP groups had greater locomotor activity, but this difference did not reach statistical significance (Figure 3E ), and distance in the open arms was greater in MPTP‐treated 6J and OlaHSD mice but non‐significantly (Figure 3F ). 3.4.

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