Ultrarare Variants in DNA Damage Repair Genes in Pediatric Acute-Onset Neuropsychiatric Syndrome or Acute Behavioral Regression in Neurodevelopmental Disorders.

Dev Neurosci · 2025 · PMC12360735 · PMID 39396515

Europe PMC DOI

hedged sentence

0.0270

closest p · 0.5× alpha

0.0270

boldest claim

The sentences

nominally significantp = 0.027actually significant

Only the ATM gene exhibited a nominally significant association ( p = 0.027), with the direction of the rare variant burden being higher in cases compared to controls, providing some statistical support for the DNA repair model.

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