High-fidelity and differential nonsense suppression in live cells and a frontotemporal dementia allele with human transfer RNAs.

Given the paucity of hits, we were not surprised that gene set enrichment analysis (GSEA) indicated no significant pathway enrichment in the cells expressing the 3-1 tRNA mutant, while only marginally significant enrichment of cell proliferation pathways related to vasculature and kidney development was found for the 4-1 nonsense suppressor, primarily driven by increased EGR1 expression rather than broader changes to the levels of multiple nodes across the associated pathways ( Supplementary Table S3 ).

also in 5,076 other papers