Integrative analysis of KEAP1/NFE2L2 alterations across 3600+ tumors reveals an NRF2 expression signature as a prognostic biomarker in cancer.

NPJ Precis Oncol · 2025 · PMC12361507 · PMID 40825842

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did not reach statistical significanceno p-value reported

Although the two curves did not reach statistical significance in the dataset from Chen et al. possibly due to the overrepresentation of patients carrying EGFR mutations, which correlated with a limited number of patients in the cluster exhibiting the NRF2 signature and the shortest OS ( p value = 0.064), the trend was consistent.

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