Effect of intravenous methotrexate carried by lipid nanoemulsion in patients with anterior ST-elevation myocardial infarction.

Nominally significant greater reductions in infarct size (% of LV) were noted in the LDE-MTX group in the modified intention-to-treat analysis (−3.9 ± 6.9 vs −9.4 ± 8.4, p = 0.030; Table 2 and Fig. 1 ) and in the per-protocol analysis (−2.7 ± 4.7 vs −8.5 ± 5.9, p = 0.024; Supplementary Table 3 ).

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