Impaired DNA damage responses and inflammatory signaling underpin hematopoietic stem cell defects in Gata2 haploinsufficiency.

Stem Cell Reports · 2025 · PMC12365849 · PMID 40749668

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did not reach statistical significanceno p-value reported

Notably, recipients of Gata2/Asxl1 double haploinsufficient HSCs exhibited lower PB engraftment than recipients of either Asxl1 +/fl ; Vav-iCre + or Gata2 +/fl ; Vav-iCre + HSCs starting from week 8, though this reduction did not reach statistical significance compared to recipients receiving Gata2 +/fl ; Vav-iCre + HSCs ( Figure S4 A).

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