Germline structural variations involving the pediatric brain tumor transcriptome include disease-relevant and ancestry-related genes.

In particular, there was a highly significant overlap ( p < 1E-16, one-sided Fisher’s exact test) between the top 56 enriched cytobands from the CBTN cohort and a top set of 79 enriched cytobands from the PCAWG cohort, involving 29 cytobands (Figure S1e).

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Nominally significant survival associations at the germline level, combined with SV-expression association and other information such as survival associations at the expression-level can help prioritize genes for further investigation.

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