Whole Exome Sequencing Study Uncovers Novel Candidate Genes and Protein-Coding Variants for Cataract.

3 , 12 Among the 32 nominally significant gene-based associations ( P < 1.00 × 10 − 4 ), six (18.75%) were issued from a missense|LC (i.e., low-confidence LoF variants) burden set, 19 (59.38%) were issued from a pLoF burden set, and seven (21.88%) were issued from a synonymous burden set ( Supplementary Figure S1 ).

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