A narrative review of reperfusion therapy in acute ischemic stroke: Emerging advances, current challenges, and future directions.

Five of these trials showed significant clinical benefit, with only one trial yielding results that were nearly statistically significant [ Table 2 ].[ 61 , 62 , 63 , 64 , 65 , 66 ] A meta-analysis of these RCTs revealed that EVT was superior to medical management in terms of enhancing functional outcomes and lowering 90-day mortality in large core infarct patients, especially those with ASPECTS of 3–5 and LVO in critical arteries such as the intracranial internal carotid artery terminus or proximal middle cerebral artery.

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