Early-Life Exposure to Bisphenol A Damaged Pancreas That May Increase Offspring Sensitivity to High-Fat Diets.

Early-Life BPA Exposure Combined With Postweaning High-Fat Diet Increases Pancreatic Ceramide Ab Initio Synthesis The abundance of ceramide molecules with different acyl chain lengths was analyzed, and the results, as shown in Figure 6 , showed an increase in the abundance of long-chain Cer (16 < C < 21) and a decrease in the abundance of very-long-chain Cer (C > 22) in both the BPA group of male mice with PND21( Figure 6(a) ) and the BPA + HFD group of PND91 ( Figure 6(c) ), whereas a clear trend was observed for the female mice (Figures 6(b) and 6(d) ).

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