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High-Fat Diet-Induced Excessive Accumulation of Cerebral Cholesterol Esters and Microglial Dysfunction Exacerbate Alzheimer's Disease Pathology in APP<sup>NL-G-F</sup> mice.

Mol Neurobiol · 2025 · PMC12367945 · PMID 40382530

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The results demonstrated that a 9-week HFD feeding resulted in a downward trend in microglial number around Aβ plaques in the cortex, though the reduction did not reach statistical significance.

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