Multi-ancestry meta-analysis of keloids uncovers novel susceptibility loci in diverse populations.

Ingenuity pathway analysis We utilized QIAGEN’s Ingenuity Pathway Analysis software 39 to determine potential upstream regulators and downstream biological functions of keloid-associated predicted gene expression, using nominally significant ( p < 0.05) GPGE results across the four meta-analyses.

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For instance, the chromosome 1 consensus result described above, corresponding to the locus at LINC01705 , was highly significant across all three ancestry-specific analyses but was superseded by other loci in the African and East Asian analyses (Fig. 3 , Supplementary Fig. 3 , Supplementary Table 3 ).

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