Gene-Environment Interaction Affects Risk of Atopic Eczema: Population and In Vitro Studies.

Allergy · 2025 · PMC12368900 · PMID 40462597

Europe PMC DOI

hedged sentence

0.0250

closest p · 0.5× alpha

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boldest claim

The sentences

nominally significantp = 0.025actually significant

In the replication analysis (254,532 individuals) dog exposure × rs10214237 (on chromosome 5p13.2 near IL7R ) was nominally significant (OR interaction = 0.91 [0.83–0.99] p = 0.025), with a risk effect of the T allele observed only in those not exposed to dogs.

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