Chronic Quetiapine Administration Has a Therapeutic Effect on Anxiety and Depression-Like Behavior in a Chronic Unpredictable Mild Stress (CUMS) Rat Model.

Similarly, in an 8‐week experimental study involving female Wistar albino rats, quetiapine administered at 10 mg/kg resulted in delayed progression through the proestrus and estrus phases in approximately 25% of animals, though these alterations did not reach statistical significance. However, a significant reduction in ovarian estrogen receptor‐α (E2Rα) immunoreactivity was reported, suggesting possible long‐term endocrine disruption (He et al. 2018 ).

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