Catheter Ablation vs Drug Therapy in Patients With Atrial Fibrillation and Nonmodifiable Recurrence Risk Factors: A Secondary Analysis of the CABANA Randomized Clinical Trial.

When patients were categorized into 3 subgroups based on NMRRF count (≤1, 2, and ≥3 NMRRFs), all exhibited significantly lower recurrence rates, highlighting a clear trend in which fewer NMRRFs led to greater reductions (≤1: AHR, 0.41 [95% CI, 0.34-0.50] and 2: AHR, 0.48 [95% CI, 0.41-0.57]; P = .01 for interaction) (eFigure 5 in Supplement 2 ).

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20 Recent meta-analyses have indicated a nonsignificant trend toward a higher recurrence risk in older patients. 21 , 22 However, the heterogeneity of the studies included in these meta-analyses necessitates caution in interpretation.

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