Impact of syndromic molecular diagnostics on antimicrobial adequacy and time to therapy in critically ill patients with pneumonia: a systematic review and meta-analysis of randomized trials.

The association between CAP proportion and antimicrobial adequacy did not reach statistical significance (coefficient = 0.86; 95% CI: -0.70 to 2.41; p = 0.28), and the test of moderators was also non-significant (QM = 1.17; p = 0.280) ( Supplementary Table S6 and Figure S10) .These findings suggest that pneumonia subtype alone does not account for the variability in adequacy outcomes across studies, and other unmeasured clinical or methodological factors may be contributing to the observed heterogeneity.

also in 111,027 other papers