Effects of caloric restriction and exercise-induced weight loss on physiological dysregulation in postmenopausal women: The mediating role of fat mass and adipose tissue distribution.

Although no baseline differences were observed between the CR and CR + Ex groups, a marginally significant time × intervention interaction (β = –0.43, p = 0.06) suggests that the addition of exercise may have attenuated the increase in PD compared to caloric restriction alone.

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• CR + exercise showed a trend toward attenuating PD progression vs.

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