AVJ16 inhibits lung carcinoma by targeting IGF2BP1.

Six out of 8 of these genes showed the same, highly significant, association with IGF2BP1 expression as was observed with AVJ16 treatment of H1299 cells, including the (one) inverse correlation with the WNT inhibitor, DKK3 (Fig. 3G ).

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Using qPCR, almost all of the WNT pathway RNAs downregulated by AVJ16 were also very significantly reduced by shIGF2BP1 knockdown, with the exception of β-catenin, that was also downregulated but did not reach statistical significance (Supplementary Fig. 3C ).

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