Human Epidermal Growth Factor Receptor 2 [HER-2/neu] Amplification and Microsatellite Stable Status in Gastric and Gastroesophageal Adenocarcinoma: Assessing Frequency and Prognostic Implications at the Cancer Institute of Iran.

Cancer Rep (Hoboken) · 2025 · PMC12375872 · PMID 40851424

Europe PMC DOI

hedged sentences

0.0530

closest p · 1.1× alpha

0.0630

boldest claim

The sentences

nearly statistically significantp = 0.053so close (0.05 < p ≤ 0.1)

The relationship between treatment modality and HER‐2 status was nearly statistically significant based on the Chi‐square test ( p = 0.053).

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marginally statistically significantp = 0.063so close (0.05 < p ≤ 0.1)

For lymphovascular invasion (LVI), 2% of cases were in the MSI‐High group and 98% in the MSI‐Negative group; this difference was marginally statistically significant ( p = 0.063).

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a nonsignificant trendno p-value reported

Conclusion HER ‐2 expression, while less common in our Iranian population compared with North American or Western European countries, showed a nonsignificant trend toward poor outcomes in patients with gastric adenocarcinoma.

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