PROS1-MERTK Axis Drives Tumor Microenvironment Crosstalk and Progression in Papillary Thyroid Microcarcinoma.

Both infla‐CAFs and myo‐CAFs showed a trend of infiltration from the tumor periphery toward the center in stage I, but this trend diminished with tumor progression, and by stage III, myo‐CAFs infiltration was nearly absent. 2.5 TAM Receptor‐Mediated Intercellular Communication in PTC To validate the expression patterns of TAM receptors (MERTK and AXL) and their ligands (GAS6 and PROS1) across various tumor stages, multiple immunofluorescence assays were conducted ( Figure 5 A , Figure S4A ).

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