Multi-Omics and -Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset.

In contrast, spleen and WAT exhibited an increasing trend for these lipids (Figure 3A ).

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Lipid groups, including LPCs, LPEs, and PCs, showed a decreasing trend in heart, kidney, and liver tissues (Figure 3A ).

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While spleen and kidney PCs were significantly reduced in control mice (FDR ≤ 0.05, Cohen's d in [−0.37, −0.46]) upon serine addition, septic mice only showed a trend, whereas serum and WAT showed sepsis‐independent alteration of serine induced lipid changes (e.g., increased PIs in both sepsis and control serum, or reduced LPCs, PCs, PIs, and phosphatidylserines (PSs) in WAT, Table S8 , Supporting Information).

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