Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration.

Paralleling the small initial increase in baseline calcium, there was a strong trend for CNO to increase activity over time vs controls in both measures of gross locomotion during the first week of treatment (two-way ANOVA distance traveled p=0.07, percent time spent moving p=0.06).

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We observed a small trend for increased fluorescent signal the day after starting CNO that persisted for days 3 through 5 but did not reach significance ( Figure 3D–F ).

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