PD-1 Bispecific Killer Engager (PD-1 BiKE) effectively depletes effector T lymphocytes in experimental autoimmune encephalomyelitis.

Front Immunol · 2025 · PMC12380559 · PMID 40881711

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did not reach statistical significanceno p-value reported

The BiKE-treated mice had, on average, 924.3 Teff in the spinal cord compared to 1,257.7 for the PBS-treated mice, while the BiKE-treated mice had 0.935 Teff/mg in the brain compared to 1.4 Teff/mg for PBS-treated mice, though the reductions did not reach statistical significance.

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