Iridium/Silver-Catalyzed H/D Exchange for Perdeuteration of Indoles and Site-Selective Deuteration of Carbazoles: Application in Late-Stage Functionalization.

For the halogen-substituted indoles ( 2e – 2h ), a clear trend in deuterium incorporation at C6 was observed with a gradual decline in the reactivity of the C–H bond, attributable to a combination of steric-electronic factors from the halogen atom, especially noticeable for 2g , wherein a corresponding decrease in H/D exchange was observed at C2.

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