Unraveling the Role of Metabolic Endotoxemia in Accelerating Breast Tumor Progression.

As shown in Figure 5 A,B, immunostaining with antibody directed against proliferation marker Ki-67 revealed a highly significant increase in the rate of BC cell proliferation in the MDA-MB-231 tumors growing under experimental ME conditions, in agreement with the greater tumor size detected in mice implanted with the endotoxin-infusing pumps ( Figure 4 A).

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We found that ME conditions resulted in twofold increase of TLR4 mRNA expression in MDA-MB-231 cells (±0.25, p value < 0.001) and 1.3 fold increase in E0771 (however, in this cell line the increase did not reach statistical significance).

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