Convergent and Divergent Mitochondrial Pathways as Causal Drivers and Therapeutic Targets in Neurological Disorders.

For mean reticulocyte volume ( n = 176 SNPs), the primary IVW estimate did not reach statistical significance; nevertheless, the pleiotropy-robust MR-Egger analysis detected a significant protective association (OR: 0.9985; 95% CI: 0.9972–0.9999; p = 0.038), collectively reinforcing the potential involvement of erythroid traits in MS pathogenesis.

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Colocalization was considered highly significant if P_4 > 0.8/0.6 (SNP.PP.H4 score), indicating strong evidence that a shared causal variant influences both the mitochondrial pathway gene and neurodegenerative disease risk. 2.5.

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