Inhibition of the Transcription Factor PU.1 Suppresses Tumor Growth in Mice by Promoting the Recruitment of Cytotoxic Lymphocytes Through the CXCL9-CXCR3 Axis.

The ratios of CD8 + T cells relative to the total live cells were substantially increased in DB-treated tumors, and the ratios of CD8 + /granzyme B + (GnzB + ) cytotoxic T cells tended to be higher in DB-treated tumors ( Figure 2 D, left two panels), although this increase did not reach statistical significance ( Figure 2 D, right panel).

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