Adenosine A2a Receptor Stimulation Mitigates Periodontitis and Is Mitoprotective in Gingival Fibroblasts Promoting Cellular Resilience.

Although not statistically significant, protein levels of Mfn2 showed a trend for increasing with the addition of CGS21680 ( Figure 5 G), and Opa1 levels were significantly higher in the presence of CGS21680 compared to control or Tnf-α-stimulated cells ( Figure 5 H), confirming the elongated aspect observed in EM with CGS21680 ( Figure 4 ), was probably indicative of increased mitochondrial fusion in mGFs.

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