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Targeting NRF2 and FSP1 to Overcome Ferroptosis Resistance in <i>TSC2</i>-Deficient and Cancer Cells.

Cancers (Basel) · 2025 · PMC12384948 · PMID 40867343

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Lysosomal load was increased in the AML and ELT3 cells lacking TSC2 , while lysosomal acidity was elevated in all TSC2 -deficient lines, although this did not reach statistical significance in the ELT3 cells.

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