Metformin Reduces Oxidative Damage in RNASEH2-Mutant Aicardi-Goutières Cells.

As shown in Figure 3 A,B, both FOXO3 and CYCS were downregulated in the NT LCLs from both RNASEH2-mutated patient cell lines compared to healthy controls, though these differences did not reach statistical significance.

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Intriguingly, following 72 h of metformin treatment, we observed a decreasing trend in ROS generation across all cell lines.

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