Barely Significant
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Genetic Insights into Hemiplegic Migraine: Whole Exome Sequencing Highlights Vascular Pathway Involvement via Association Analysis.

Genes (Basel) · 2025 · PMC12386144 · PMID 40869943

Europe PMCDOI
2
hedged sentences
0.1210
closest p · 2.4× alpha
0.1210
boldest claim

The sentences

did not reach statistical significancep = 0.121not close (p > 0.1)
In contrast, the COL4A2 p.Glu1123Gly variant, though more common in the HM cohort (n = 8, MAF = 0.022), did not reach statistical significance (χ 2 = 2.41, p = 0.121).

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highly significantno p-value reported
Chi-square analysis, presented in Table 2 , showed a highly significant association for this variant with a chi-square value of 25.11 and a p -value of 5.41 × 10 −7 .

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