A difference was considered statistically significant when the p-value was less than 0.05 and highly significant if it was less than 0.01 or less than 0.001.
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<i>ZC3H11A</i> mutations cause high myopia by triggering PI3K-AKT and NF-κB-mediated signaling pathway in humans and mice.
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Here we provide point-by-point responses to your valuable comments: Our study demonstrates that Zc3h11a heterozygous mutant mice exhibit myopic refractive phenotypes with upregulated myopia-associated factors (TGF-β1, MMP2, and IL6), although axial elongation did not reach statistical significance.
While these differences did not reach statistical significance at other time points, an increasing trend was still observed.