Adverse Childhood Experiences, Genetic Susceptibility, and the Risk of Osteoporosis: A Cohort Study.

Medicina (Kaunas) · 2025 · PMC12388128 · PMID 40870432

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an increasing trendno p-value reported

An increasing trend in osteoporosis risk was noted with higher levels of both ACEs and PRSs.

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did not reach statistical significanceno p-value reported

In addition, when examining the joint effects of genetic risk and ACEs, participants with high ACEs and high genetic risk showed the highest risk of incident osteoporosis, but the G × E interaction did not reach statistical significance. 4.2.

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