Integrating Cartilage Explant Culture with Simulated Digestion and Hepatic Biotransformation Refines In Vitro Screening of Joint Care Nutraceuticals.

And while the difference between G sim -T5+ and G sim -T5 did not reach statistical significance, it is plausible that this may have resulted from the higher dose stimulating more LPS-mediated proteoglycan synthesis in stimulated explants, as has been reported by others [ 13 ], which may have reduced the difference in GAG retention between stimulated and unstimulated cartilage explants.

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